Laboratory-based diagnosis of pneumococcal pneumonia: state of the art and unmet needs
Identifieur interne : 006961 ( Main/Exploration ); précédent : 006960; suivant : 006962Laboratory-based diagnosis of pneumococcal pneumonia: state of the art and unmet needs
Auteurs : G. Vernet [France] ; S. Saha [Bangladesh] ; C. Satzke [Australie] ; D. H. Burgess ; M. Alderson [États-Unis] ; J.-F. Maisonneuve [États-Unis] ; B. W. Beall [États-Unis] ; M. C. Steinhoff [États-Unis] ; K. P. Klugman [Afrique du Sud, États-Unis]Source :
- Clinical microbiology and infection. Supplement [ 1470-9465 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
In view of the increasing use of pneumococcal vaccines, especially in the developing world, there is a need for appropriate diagnostics to understand the aetiology of pneumonia, to define the burden of pneumococcal disease, and to monitor vaccine efficacy and effectiveness. This article summarizes a meeting on the diagnosis, detection and serotyping of pneumococcal disease organized by PATH and Fondation Mérieux (I8-20 October 2009, Fondation Merieux Conference Centre, Les Pensieres, France). Workers and experts met to discuss the gaps in the microbiology-based diagnosis of Streptococcus pneumoniae disease, with special emphasis on pneumonia. The meeting was designed to evaluate the state of the art of pneumococcal diagnostics and serotyping methodologies, identify research and development needs, and propose new guidelines to public health authorities to support the introduction of vaccines. Regarding detection, the main recommendations were to encourage chest X-rays and antigen detection in urine. Large-scale studies are needed to evaluate the diagnostic utility of test algorithms that associate chest X-rays, antigen detection in urine, S. pneumoniae quantitative PCR in nasopharyngeal aspirates and sputum, and C-reactive protein or procalcitonin measurement in blood. Efforts should be focused on proteomics to identify pneumococcus-specific antigens in urine or host markers in blood expressed during pneumonia. It was recommended to develop S. pneumoniae typing capacities, to understand the epidemiology of pneumococcal disease, and to evaluate vaccine effectiveness. Simple and effective approaches are encouraged, and new technologies based on beads, microarrays or deep sequencing should be developed to determine, in a single test capsular serotype, resistance profile and genotype.
Affiliations:
- Afrique du Sud, Australie, Bangladesh, France, États-Unis
- Auvergne-Rhône-Alpes, Gauteng, Rhône-Alpes, Victoria (État)
- Johannesbourg, Lyon, Melbourne
- Université de Melbourne, Université du Witwatersrand
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Vernet</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Fondation Mérieux</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Saha, S" sort="Saha, S" uniqKey="Saha S" first="S." last="Saha">S. Saha</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, Bangladesh Institute of Child Health, Child Health Research Foundation, Dhaka Shishu Hospital</s1><s2>Dhaka</s2><s3>BGD</s3><sZ>2 aut.</sZ></inist:fA14><country>Bangladesh</country><wicri:noRegion>Dhaka</wicri:noRegion></affiliation></author><author><name sortKey="Satzke, C" sort="Satzke, C" uniqKey="Satzke C" first="C." last="Satzke">C. 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Alderson</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>PATH</s1><s2>Seattle, WA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>PATH</wicri:noRegion></affiliation></author><author><name sortKey="Maisonneuve, J F" sort="Maisonneuve, J F" uniqKey="Maisonneuve J" first="J.-F." last="Maisonneuve">J.-F. Maisonneuve</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>PATH</s1><s2>Seattle, WA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>PATH</wicri:noRegion></affiliation></author><author><name sortKey="Beall, B W" sort="Beall, B W" uniqKey="Beall B" first="B. W." last="Beall">B. W. Beall</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Respiratory Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, GA</wicri:noRegion></affiliation></author><author><name sortKey="Steinhoff, M C" sort="Steinhoff, M C" uniqKey="Steinhoff M" first="M. C." last="Steinhoff">M. C. Steinhoff</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>The Johns Hopkins Medical Institution</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>The Johns Hopkins Medical Institution</wicri:noRegion></affiliation></author><author><name sortKey="Klugman, K P" sort="Klugman, K P" uniqKey="Klugman K" first="K. P." last="Klugman">K. P. Klugman</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council, University of the Witwatersrand</s1><s2>Johannesburg</s2><s3>ZAF</s3><sZ>9 aut.</sZ></inist:fA14><country>Afrique du Sud</country><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Hubert Department of Global Health, Rollins School of Public Health and Division of Infectious Diseases, School of Medicine, Emory University</s1><s2>Atlanta, GA</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, GA</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Clinical microbiology and infection. Supplement</title><title level="j" type="abbreviated">Clin. microbiol. infect., Suppl.</title><idno type="ISSN">1470-9465</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical microbiology and infection. Supplement</title><title level="j" type="abbreviated">Clin. microbiol. infect., Suppl.</title><idno type="ISSN">1470-9465</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Diagnosis</term><term>Laboratory</term><term>Microbiology</term><term>Pneumococcal infection</term><term>Pneumonia</term><term>Serotype</term><term>Serotyping</term><term>Streptococcus pneumoniae</term><term>Typing</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pneumococcie</term><term>Pneumonie</term><term>Laboratoire</term><term>Diagnostic</term><term>Sérotypie</term><term>Streptococcus pneumoniae</term><term>Sérotype</term><term>Typage</term><term>Microbiologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In view of the increasing use of pneumococcal vaccines, especially in the developing world, there is a need for appropriate diagnostics to understand the aetiology of pneumonia, to define the burden of pneumococcal disease, and to monitor vaccine efficacy and effectiveness. This article summarizes a meeting on the diagnosis, detection and serotyping of pneumococcal disease organized by PATH and Fondation Mérieux (I8-20 October 2009, Fondation Merieux Conference Centre, Les Pensieres, France). Workers and experts met to discuss the gaps in the microbiology-based diagnosis of Streptococcus pneumoniae disease, with special emphasis on pneumonia. The meeting was designed to evaluate the state of the art of pneumococcal diagnostics and serotyping methodologies, identify research and development needs, and propose new guidelines to public health authorities to support the introduction of vaccines. Regarding detection, the main recommendations were to encourage chest X-rays and antigen detection in urine. Large-scale studies are needed to evaluate the diagnostic utility of test algorithms that associate chest X-rays, antigen detection in urine, S. pneumoniae quantitative PCR in nasopharyngeal aspirates and sputum, and C-reactive protein or procalcitonin measurement in blood. Efforts should be focused on proteomics to identify pneumococcus-specific antigens in urine or host markers in blood expressed during pneumonia. It was recommended to develop S. pneumoniae typing capacities, to understand the epidemiology of pneumococcal disease, and to evaluate vaccine effectiveness. Simple and effective approaches are encouraged, and new technologies based on beads, microarrays or deep sequencing should be developed to determine, in a single test capsular serotype, resistance profile and genotype.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Australie</li><li>Bangladesh</li><li>France</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Gauteng</li><li>Rhône-Alpes</li><li>Victoria (État)</li></region><settlement><li>Johannesbourg</li><li>Lyon</li><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li><li>Université du Witwatersrand</li></orgName></list><tree><noCountry><name sortKey="Burgess, D H" sort="Burgess, D H" uniqKey="Burgess D" first="D. H." last="Burgess">D. H. Burgess</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Vernet, G" sort="Vernet, G" uniqKey="Vernet G" first="G." last="Vernet">G. Vernet</name></region></country><country name="Bangladesh"><noRegion><name sortKey="Saha, S" sort="Saha, S" uniqKey="Saha S" first="S." last="Saha">S. Saha</name></noRegion></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Satzke, C" sort="Satzke, C" uniqKey="Satzke C" first="C." last="Satzke">C. Satzke</name></region></country><country name="États-Unis"><noRegion><name sortKey="Alderson, M" sort="Alderson, M" uniqKey="Alderson M" first="M." last="Alderson">M. Alderson</name></noRegion><name sortKey="Beall, B W" sort="Beall, B W" uniqKey="Beall B" first="B. W." last="Beall">B. W. Beall</name><name sortKey="Klugman, K P" sort="Klugman, K P" uniqKey="Klugman K" first="K. P." last="Klugman">K. P. Klugman</name><name sortKey="Maisonneuve, J F" sort="Maisonneuve, J F" uniqKey="Maisonneuve J" first="J.-F." last="Maisonneuve">J.-F. Maisonneuve</name><name sortKey="Steinhoff, M C" sort="Steinhoff, M C" uniqKey="Steinhoff M" first="M. C." last="Steinhoff">M. C. Steinhoff</name></country><country name="Afrique du Sud"><region name="Gauteng"><name sortKey="Klugman, K P" sort="Klugman, K P" uniqKey="Klugman K" first="K. P." last="Klugman">K. P. Klugman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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